The global upstream bioprocessing market is anticipated to grow at a CAGR of 11.1% during the forecast period (2023-2030). The main use of upstream bioprocessing is to achieve large-scale cell growth from small amounts from a variety of cell lines. The key factor driving the market is the growing implementation of the Process Analytical Technology (PAT) strategy as a mechanism to design, analyze, and optimize processes through timely measurements of critical process parameters. PAT is utilize to examine the performance of cell culture production based on parameters such as real-time nutrient analysis and inline monitoring of cell density. An increase in the productivity of cell lines has significantly improved the performance of upstream processing in terms of capital requirement and process reproducibility, as the highly productive cultures involve low operating costs and the use of smaller bioreactors.
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Maintaining the film’s integrity is crucial to ensure product quality, sterility, and reliable manufacturing operations in single-use bioprocessing upstream. Considering viral and bacterial contamination as a constant threat to the process, key market player are engaging in the development of novel products to mitigate the contamination risk and diminish the chances of attrition of the final product. For instance, in April 2023, Merck KGaA launched Ultimus, a single-use bioprocessing upstream container film aimed to offer extreme durability along with leak resistance for single-use assemblies used for bioprocessing liquid applications.
Bioreactor system gives users a streamlined way to control cell growth and improve cell retention in perfusion processes without using a separate cell retention control tower. For instance, in August 2023, The life science group Sartorius and Repligen Corp. launched of an integrated bioreactor system that incorporates Repligen XCell® ATF upstream intensification technology into Sartorius’ Biostat STR® bioreactor, simplifying intensified seed train and N perfusion implementation for biopharmaceutical manufacturers. The Biostat STR® now contains a fully compatible embedded XCell® ATF hardware and software module offering predefined advanced control recipes with integrated Process Analytical Technology (PAT).
Bioreactor enabling biopharmaceutical companies to integrate single-use technologies into large-scale bioprocesses, including perfusion cell culture and cGMP manufacturing at very high cell density. For instance, in March 2021, Thermo Fisher Scientific Launched 3,000 L and 5,000 L HyPerforma DynaDrive Single-Use Bioreactors (S.U.B.s) for cell culture production. By minimizing seed-train and enabling large-scale, high-intensity processes, the DynaDrive S.U.B.s reduce overall costs through reduced capital investment, reduced operational expenses, and higher-output processes.
Market Coverage
- The market number available for – 2022-2030
- Base year- 2022
- Forecast period- 2023-2030
- Segment Covered-
o By Product
o By Workflow
o By Use Type
- Regions Covered-
o North America
o Europe
o Asia-Pacific
o Rest of the World
- Competitive Landscape- includes Corning, Inc., Eppendorf AG, Merck KGaA, Sartorius AG, Thermo Fisher Scientific Inc., and others.
Key questions addressed by the report
- What is the market growth rate?
- Which segment and region dominate the market in the base year?
- Which segment and region will project the fastest growth in the market?
- Who is the leader in the market?
- How are players addressing challenges to sustain growth?
- Where is the investment opportunity?
Global Upstream Bioprocessing Market Report Segment
By Product
- Bioreactors
- Cell Culture Products
- Filters
- Bags and Containers
- Others (Bioreactors Accessories)
By Workflow
- Media Preparation
- Cell Culture
- Cell Separation
By Use Type
- Multi-Use
- Single-Use
A full report of Upstream Bioprocessing Market available @ https://www.omrglobal.com/industry-reports/upstream-bioprocessing-market
Company Profiles
- AGC Inc.
- Applikon Biotechnology
- Bio-Connect Inc.
- BioProcess International
- Boehringer Ingelheim GmbH
- CellGenix GmbH
- Cytiva LifeScience
- Danaher Corp.
- Eppendorf AG
- Esco Pharma
- Getinge AB
- Infors HT
- Lonza Group Ltd.
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