The global lamotrigine market is anticipated to grow at a significant CAGR during the forecast period. Epilepsy has long been treated using voltage-gated sodium channel blockers such as phenytoin and carbamazepine. Many modern second-generation (fosphenytoin, oxcarbazepine, lamotrigine, felbamate, topiramate, zonisamide) and third-generation antiepileptic medicines (eslicarbazepine, brivaracetam, carisbamate, fluorofelbamate, elpetrigine, lacosamide, rufinamide, safinamide, vinpocetine) (AEDs). Although most medications do not differentiate between these channel subtypes, several of the newer treatments exhibit either state-dependent antiepileptic efficacy of sodium channel subtype selectivity. Preclinical and clinical efficacy, pharmacokinetics, medication interactions, and adverse event patterns are highlighted in this review. It also covers the sodium channel.
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Over the last decade, there has been significant improvement in the treatment of epilepsy, with the introduction of eight new anticonvulsants and an innovative neurostimulation device. When it comes to therapeutic decisions, clinicians are faced with a profusion of possibilities. Only after thorough randomized controlled studies have novel antiepileptic medicines (AEDs) or devices been approved for sale. Add-on trials, in that patients with refractory epilepsy who are on stable AED therapy, are randomized to receive a study drug or a placebo, are the most prevalent designs for initial AED efficacy trials. This method can be criticized. Patients with refractory epilepsy make up a small percentage of the epilepsy community, hence the findings may not be applicable to the general population. Furthermore, partial epilepsy is not a one-size-fits-all condition. In add-on studies, drug interactions can be a difficult confounding factor.
Monotherapy trials, which are normally conducted after add-on trials have been successful, often involve newly diagnosed patients and provide the most accurate assessment of a drug’s efficacy and tolerability. Monotherapy with current anticonvulsants, on the other hand, resolves complex partial seizures in up to 40% to 50% of patients1, making placebo-controlled monotherapy trials unethical.
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Market Coverage
Segment Covered-
- By Type
- By Application
Regions Covered-
- North America
- Europe
- Asia-Pacific
- Rest of the World
Competitive Landscape- Lamotrigine market Lamotrigine Tetrahedron Manufacturing Services, Polpharma Company, Vignesh Life Sciences, Jubilant FoodWorks Limited, IOL Chemicals and Pharmaceuticals Limited, and Veeprho Pharmaceuticals s.r.o.
Key questions addressed by the report
- What is the market growth rate?
- That segment and region dominate the market in the base year?
- That segment and region will project the fastest growth in the market?
- How does COVID-19 impact the market?
o Deviation from the pre-COVID-19 forecast
o Most affected region and segment
- Who is the leader in the market?
- How players are addressing challenges to sustain growth?
- Where is the investment opportunity?
Global Lamotrigine Market Report by Segment
By Type
- Purity 98%-99%
- Purity 99%
By Application
- Epilepsy
- Bipolar Disorder
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