The global hypoxia inducible factor alpha inhibitor market is anticipated to grow at a significant CAGR during the forecast period (2021-2027). Hypoxia-inducible factors (HIFs) are transcript factors responding to reductions in presented oxygen in the cellular environment or hypoxia. The major factor driving the growth of the market is the increasing prevalence of cancer across the globe. According to the National Cancer Institute (NCI), it was estimated that 1,806,590 new cases of cancer will be diagnosed in the US with a mortality rate of 606,520 people in 2020. Furthermore, there were 18.1 million new cases and 9.5 million cancer-related mortalities globally in 2018 which is anticipated to rise to 29.5 million and the number of cancer-related mortalities to 16.4 million by 2040. Hence, the rising prevalence of cancer is driving the demand for hypoxia inducible factor alpha inhibitors. The HIF-alpha is a major regulator of tumor angiogenesis. Histone deacetylase (HDAC) and Mammalian target of rapamycin (mTOR) inhibitors suppress tumor-induced angiogenesis by reducing tumor HIF-1 alpha protein expression.
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Some major players operating in the market include Merck & Co., Inc., and Astellas Pharma Inc., among others. The market players are contributing significantly to the growth of the market by the adoption of various strategies including mergers & acquisitions, geographical expansion, partnerships and collaborations, and new product launches, to stay competitive in the market. For instance, in August 2021, Merck announced the approval of WELIREG from the US Food and Drug Administration (FDA). It is an oral hypoxia-inducible factor-2 alpha (HIF-2?) inhibitor that is used for the treatment of adult patients with von Hippel-Lindau (VHL) disease.
Market Coverage
- The market number available for – 2020-2027
- Base year- 2020
- Forecast period- 2021-2027
Segment Covered-
- By Type
- By Application
Regions Covered-
- North America
- Europe
- Asia-Pacific
- Rest of the World
Competitive Landscape- Merck & Co., Inc., and Astellas Pharma Inc., among others.
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Global Hypoxia Inducible Factor Alpha Inhibitor Market Report by Segment
By Type
- HIF-1?
- HIF-2?
- HIF-3?
By Application
- Solid Tumor
- Acute Myelocytic Leukemia
- Cancer
- Others
Global Hypoxia Inducible Factor Alpha Inhibitor Market Report by Region
North America
- United States
- Canada
Europe
- UK
- Germany
- Spain
- France
- Italy
- Rest of Europe
Asia-Pacific
- India
- China
- Japan
- South Korea
- Rest of APAC
Rest of the World
- Latin America
- Middle East & Africa
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