The global dental bone graft substitutes market is expected to grow at a CAGR of 7.2% during the forecast period (2024-2031). In dentistry, bone graft substitutes are used to repair and rebuild bone tissue in the jaw, which can often be destroyed due to illness or injury. There are numerous types of bone graft alternatives available, including allografts, demineralized allografts, synthetic grafts, and xenografts. Allografts are manufactured from donated human bone tissue, whereas demineralized allografts are treated to eliminate mineral content, making them easier for the body to absorb. Synthetic grafts are created from materials such as calcium phosphate, which can be molded to match the patient’s needs. Xenografts are obtained from animal sources such as bovine or porcine bone.
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Popular bone graft substitutes in terms of product segmentation include Bio-Oss, Grafton, and Osteograf. Bio-Oss is a naturally occurring, porous bone mineral obtained from bovine sources that have been scientifically proven to stimulate bone formation. Grafton is a demineralized bone matrix generated from human tissue that has osteoinductive capabilities. Osteograf is a synthetic graft material that is noted for its biocompatibility and convenience of usage. It is utilized in a number of dental treatments.
Bone graft replacements are utilized in a wide range of dental operations, including implant bone regeneration, periodontal defect regeneration, ridge augmentation, sinus lift, and socket preservation. The most prevalent use is implant bone regeneration, in which bone graft substitutes are utilized to create a solid base for dental implants.
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Key Drivers of the Dental Bone Graft Substitutes Market
Increasing Prevalence of Periodontitis and Dental Caries
The increasing incidence of dental diseases such as periodontitis and dental caries is one of the key drivers of the dental bone graft substitutes market. According to the World Health Organization, almost 3.5 billion people worldwide suffer from oral diseases. Additionally, according to the Centers for Disease Control and Prevention (CDC), data updated in January 2021, one in every four individuals aged 20 to 64 has at least one cavity, while over 57% of teenagers aged 12 to 19 have a hole in their permanent teeth. Besides, according to the CDC’s December 2020 statistics, more than one in four (26%) adults have untreated tooth decay, nearly half (46%) of all adults aged 30 years or older have signs of gum disease, and severe gum disease affects approximately 9% of adults in the US. These oral disorders can cause considerable damage to the jawbone, necessitating the use of bone transplant substitutes to repair lost bone tissue.
Increasing Demand for Dental Implants
The rising need for dental implants is another major driver of the dental bone graft substitute market. Dental implants are a common treatment option for people who have lost teeth due to injury, illness, or other causes. Dental implants require a solid foundation of healthy bone tissue to be successful. To create this foundation, bone graft replacements are frequently employed, allowing the patient to get a successful implant.
Technological Advancements
Technological improvements are fueling the growth of the dental bone graft substitutes market. The development of novel materials and processes for bone graft replacements has resulted in greater efficacy, safety, and affordability of these products. The utilization of computer-aided design and 3D printing technologies is also changing bone graft replacement manufacture and personalization. For instance, in November 2022, Lithoz launched the LithaBone HA 480 for 3D-printed bone replacements. The substance, a bioresorbable ceramic bone graft substitute, was created in ‘intense cooperation’ with users of earlier Lithoz bone graft substitute products. LithaBone HA 480 from Lithoz allows for substantially larger wall thicknesses than earlier Lithoz bone replacement materials, ranging from 1.6mm to 10mm, while also demonstrating “strongly reduced overpolymerisation with an improved depth of cure for a more stable manufacturing process.” The company also states that the LithaBone HA 480 has a ten-fold longer shelf life and allows for easier-to-clean parts, resulting in better availability and speedier procedures.
Expansions and Innovations by Major Market Players
The dental bone graft substitutes market has significant contributors such as Institut Straumann AG, Medtronic PLC, Dentsply Sirona, Johnson & Johnson, Zimmer Biomet Holdings Inc., Geistlich Pharm, Collagen Matrix Inc., Halma plc (Novabone LLC), Dentium, LifeNet Health, Botiss biomaterials GmbH, and Wright Medical Group NV, among others. These players assist in the market’s growth with the launch of new products and through collaborations and investments. Some of the recent developments in the market include-
- In March 2022, the Central Drugs Standard Control Organisation (CDSCO) in India granted Fredun Pharmaceuticals Ltd. permission to manufacture Xenografts for different dentistry and orthopedic surgery products. The company intends to use this to penetrate the dental fraternity across India.
- In March 2022, Biocomposites signed a distribution agreement with Zimmer Biomet for the novel Genex Bone Graft Substitute. Genex Bone Graft Substitute is a biphasic composite of exceptional purity that has been specially developed to balance osteoconductive scaffold strength and durability in the body, allowing for optimum bone architecture remodeling.
- In March 2022, CGbio, a regenerative medicine company, announced a five-year contract for 10 billion KRW ($7.5 million) with Kerunxi Medical, a Chinese dental equipment manufacturer, for the sale of Bongros Dental, a bone graft substance. Bongros is a hydroxyapatite ceramic bone replacement that is crystallographically and chemically equivalent to the inorganic components of human bones. It is used to replace and repair damaged bone implants. After being transplanted into the human mouth, it has a pore structure (300 ?m) that allows for the rapid development of new bone and blood vessels while immediately attaching to the surrounding bone tissue.
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